Is Chicago the center of American Design Thinking?

Likely so. While the AIGA will want to tell you that it is New York, design has rapidly moved beyond fashion. The folks steering d.school at Stanford have some pretty high aspirations and they will likely get there, but boatloads of money and bunch of PhD's don't necessarily make you great. Carnagie Mellon is absolutely a player. But when it comes to pushing the envelope of design and design's practical applications - IIT/ID is at the forefront. This is not to say it is the best design school, that is a personal decision for each and every design student. But I think critical to what ID brings us is their lack of an undergraduate program. They have picked a specific area/market and doing extraordinary things. Last May's Strategy conference was possibly the best assemblies I have attended (and some say it was a down year). If you have not been to on, I highly recommend it.